Pentagastrin induced a hyperaemic response to luminal acid challenge, increased mucus gel thickness, and elevated pH i during acid challenge.
This gastroprotection was abolished by ranitidine, but not omeprazole or pyrilamine. Results-Pentagastrin protected rat gastric mucosa from acidified aspirin injury. The effects of these compounds on pentagastrin enhanced gastroprotective mechanisms were investigated using intravital microscopy, in which intracellular pH of gastric surface cells (pH i), mucus gel thickness, gastric mucosal blood flow, and acid output were measured simultaneously. Methods-The effects of omeprazole (100 μmol/kg), ranitidine (20 mg/kg), and pyrilamine (10 mg/kg) on pentagastrin (80 μg/kg/h) induced gastroprotection against acidified aspirin injury were examined in a luminal pH controlled model. Background-Pentagastrin enhances gastric mucosal defence mechanisms against acid and protects the gastric mucosa from experimental injury.Īims-To investigate whether this gastroprotection is mediated by histamine receptors or occurs as a secondary effect of acid secretion stimulation.
